Novedades Bibliográficas
En esta sección se pretende presentar libros de aparición
reciente, de interés en el campo de la Farmacia Industrial y Galénica.
Si se desea incluir alguna reseña de una obra, ésta deberá incluir: título,
autor, editorial, ISBN, número de páginas, área de utilidad, complejidad,
precio (si se conoce) y un comentario (aproximadamente 200 palabras) y se
dirigirá a info@sefig.com
| Editados en los años 2001, 2002 y 2003 |
MANUAL
DE FARMACIA PRÁCTICA.
Mª Adolfina Ruiz Martínez
Editorial Universidad de Granada
MANUAL DE FARMACIA CLÍNICA Y ATENCIÓN FARMACÉUTICA
Manual of Clinical Pharmacy and Phamaceutical Care
"Instalaciones de Producción Farmacéutica. Diseño y aplicaciones" AEFI
Novedades Bibliográficas comentadas
| Tecnología Farmacéutica, Biofarmacia | |||
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Normas de correcta fabricación medicamentos de uso humano y
medicamentos veterinarios ISBN: 84-7670-599-9 2002 Nº páginas: 250 Precio aproximado: 8,85 € |
En 1991, la Comisión de las Comunidades Europeas adoptó dos Directivas por las que se establecen los principios y directrices de las Normas de correcta fabricación para los medicamentos. La primera se refiere a los medicamentos de uso humano (Directiva 91/356/CEE) y la segunda a los medicamentos veterinarios (Directiva 91/412/CEE). La presente guía de buenas prácticas de fabricación contiene directrices detalladas establecidas de acuerdo con estos principios. Esta guía se utilizará para evaluar las solicitudes de autorización de fabricación, y será igualmente utilizada como base para las inspecciones de los fabricantes de medicamentos. | ||
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WHO expert committee on specifications for pharmaceutical
preparations Editorial: ORGANIZACION MUNDIAL DE LA SALUD 2004, 125 Págs., ISBN: 92-4-120917-8, 38ª Edic., Rústica Precio aproximado: 20,73 Euros |
This report presents the recommendations of an international group of experts convened by the World Health Organization to consider matters concerning the quality assurance of pharmaceuticals and specifications for drug substances and dosage forms. Of particular relevance to drug regulatory authorities and pharmaceutical manufacturers, this report discusses the latest volume of the International Pharmacopoeia and quality specifications for pharmaceutical substances and dosage forms, as well as quality control of reference materials, good manufacturing practices (GMP), inspection, distribution and trade and other aspects of quality assurance of pharmaceuticals, and regulatory issues. The report is complemented by a number of annexes, including recommendations on good trade and distribution practices for pharmaceutical starting materials, guidelines on the WHO scheme for the certification of pharmaceutical materials moving in international commerce, draft procedures for assessing quality control laboratories and procurement agencies for use by the United Nations agencies, and guidelines for preparing a laboratory information file and a procurement agency information file. | ||
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Gassmann, O. Reepmeyer, G. Zedtwitz, M. von China P.R. Leading pharmaceutical innovation: trends and drivers for growth in the pharmaceutical industry Editorial: SPRINGER VERLAG GmbH & Co.KG 2004, 178 Págs., ISBN: 3-540-40717-0, Cartoné Precio aproximado: 51,95 Euros |
Pharmaceutical giants have been doubling their investments
in drug development, only to see new drug approvals to remain constant for
the past decade. This book investigates and highlights a set of proactive
strategies. The authors focus on three sources of pharmaceutical
innovation: new management methods, new technologies, and new forms of
internationalization. Their findings are illustrated in the case of the
Swiss pharmaceutical industry, the leading exporter of pharmaceutical
products in percentage of GDP, and some of its main pharmaceutical firms
such as Novartis and Hoffmann-La Roche.
INDICE = Innovation as a Key Success Factor in the Pharmaceutical Industry.- Pharmaceutical Innovation: The Case of Switzerland.- The Science and Technology Challenge: How to Find New Drugs.- The Pipeline Management Challenge: How to Shape the Innovation Flow.- The Outsourcing and Internationalization Challenge: How to Harness Outside Innovation.- Management Answers to Pharmaceutical R&D Challenges.- Future Directions and Trends.- Appendix. |
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Mutnick, Alan H.; Shargel, Leon; Souney, Paul F.;Swanson, Larry N. Comprehensive pharmacy review practice exams Editorial: LIPPINCOTT WILLIAMS & WILKINS 2004, 176 Págs., ISBN: 0-7817-4485-7, 5ª Edic. Precio aproximado: 29,50 Euros |
Revised to reflect the current progress of pharmacy education and practice, this book contains practice exams for the best-selling NAPLEX review guide, Comprehensive Pharmacy Review, 5 edition. The practice questions cover all the subjects in the pharmacy school curriculum and provide both guidance and test practice for NAPLEX candidates. The text and practice exams will be valuable to all pharmacy undergraduates and professionals who seek detailed summaries of topics central to the study of pharmacy-chemistry, pharmaceutics, pharmacology, pharmacy practice, and drug therapy. These topics are organized to parallel the pharmacy curriculum and presented in outline form for easy use. Related Products: | ||
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Manual del auxiliar de farmacia: temario general : módulo II :
farmacía práctica Editorial: EDITORIAL MAD,S.L. 2004, 366 Págs., ISBN: 84-665-2923-3, Rústica Precio aproximado: 30,50 Euros |
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Aulton, M.E. Farmacia: la ciencia del diseño de las formas farmacéuticas Editorial: MOSBY-DOYMA 2004, 696 Págs., ISBN: 84-8174-728-9, 2ª Edic., Rústica Precio aproximado: 59,00 Euros |
Segunda edición de un texto de éxito mundial, cuya primera edición
publicada en 1988 se ha estado utilizando como texto, de manera continuada
desde esta fecha, en muchas Facultades de Farmacia de todo el mundo. El
objetivo de esta obra es proporcionar a los farmacéuticos los
conocimientos necesarios para convertir una droga potencial en un fármaco
que pueda ser administrado al paciente de una manera segura y eficiente.
Trata de manera exhaustiva la Ciencia del diseño de las formas farmacéuticas
y todos los modos de presentación de los fármacos. En su sentido amplio
esta obra es una ôCiencia de la boticaö o de las preparaciones farmacéuticas,
por lo que es materia fundamental dentro del currículo universitario y
dentro de la profesión de farmacéutico. Incluye el diseño y formulación
de fármacos, para lo que se enseñan los aspectos de química física
necesarios, su producción a pequeña escala (compuestos) y a gran escala
(tecnología farmacéutica) y la eliminación de microorganismos de los fármacos.
Aunque las ciencias básicas permanecen prácticamente invariables, hay
otros campos como la biofarmacia, algunos aspectos de la administración
de fármacos, las propiedades del estado sólido y productos de
biotecnología que sí han cambiado, por lo que se hacía indispensable
una nueva edición de este exitoso texto, que profesores y alumnos han
estado reclamando durante los últimos años. Esta nueva edición está
estructurada en cinco partes: 1) Principios Científicos del diseño de
las formas farmacéuticas; 2) Ciencia de las partículas y tecnología
relacionada con el polvo; 3) Principios biofarmacéuticos de la
administración de fármacos; 4) Diseño y fabricación de las formas
farmacéuticas; 5) Microbiología farmacéutica; a lo largo de las que se
cubre completamente los contenidos de las asignaturas de Galénica y
Tecnología Farmacéutica, por lo que esta obra es el recurso más
reconocido y difundido para el estudio de estas materias.
INDICE: El diseño de las formas farmacéuticas. I. Principios científicos del diseño de las formas farmacéuticas. Disolución y solubilidad. Propiedades de las soluciones. Reología. Fenómenos superficiales y de interfase. Sistemas dispersos. Cinética y estabilidad del producto. Preformulación farmacéutica. II. Ciencia de las partículas y tecnología relacionada con el polvo. Propiedades del estado sólido. Análisis del tamaño de las partículas. Reducción del tamaño de las partículas. Separación por el tamaño de las partículas. Mezclado. Flujo de polvo. III. Principios biofarmacéuticos de la administración de fármacos. Introducción a la biofarmacia. El aparato digestivo: fisiología y absorción farmacológica. Biodisponibilidad: factores fisicoquímicos y de la forma farmacéutica. Evaluación de las propiedades biofarmacéuticas. Regímenes posológicos. Stuart Proudfoot, (actualizado por John Collett). Forma farmacéutica oral de liberación modificada. III. Principios biofarmacéuticos de la administración de fármacos. Introducción a la biofarmacia. El aparato digestivo: fisiología y absorción farmacológica. Biodisponibilidad: factores fisicoquímicos y de la forma farmacéutica. Evaluación de las propiedades biofarmacéuticas. Regímenes posológicos. Stuart Proudfoot, (actualizado por John Collett). Forma farmacéutica oral de liberación modificada. IV. Diseño y fabricación de las formas farmacéuticas. Soluciones. Aclaramiento. Suspensiones y emulsiones. Polvos y gránulos. Granulación. Secado. Comprimidos y compactación. Recubrimiento de comprimidos y multipartículas. Cápsulas de gelatina dura. Cápsulas de gelatina blanda. Administración de fármacos por vía pulmonar. Administración de fármacos por vía nasal. Administración de fármacos por vía transdérmica. Administración de fármacos por vía rectal y vaginal. Administración de proteínas farmacéuticas. Envases y envasado. Diseño de una planta farmacéutica. Transferencia de calor y propiedades y empleo de vapor... |
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Bolton Sanford; Bon, Charles Pharmaceutical statistics: practical and clinical applications Editorial: MARCEL DEKKER, INC. (NEW YORK) 2003, 650 Págs., ISBN: 0-8247-4695-3, 4ª Edic., Cartoné Precio aproximado: 237,01 Euros (IVA incluido), |
Includes a disk with special programs to aid in problem analysis. Presents
fresh material on concept conformity and release targets. Describes linear
regression and correlation, the analysis of variance, and crossover
designs.
INDICE: Basic Definitions and Concepts. Data graphics. Introduction to Probability: The Binomial and Normal Probability Distributions. Choosing Samples. Statistical Inference: Estimation and Hypothesis Testing. Sample Size and Power. Linear Regression and Correlation. Analysis of Variance. Factorial Designs. Transformations and Outliers. Experimental Design in Clinical Trials. Quality Control. Validation. Computer-Intensive Methods. Nonparametric Methods. Optimization Techniques and Screening Designs. Appendix I: Some Properties of the Variance. Appendix II: Comparison of Slopes and Testing of Linearity: Determination of Relative Potency. Appendix III: Multiple Regression. Appendix IV: Tables. Appendix V: Outlier Tests and Chemical Assays. Appendix VI: Should a Single Unexplained Failing Assay Be Reason to Reject a Batch. Answers to Exercises. Index. |
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Ho, Rodney J.; Gibaldi, Milo Biotechnology and biopharmaceuticals: transforming proteins and genes into drugs Editorial: JOHN WILEY & SONS, LTD.(2ª) 2003, 556 Págs., ISBN: 0-471-20690-3, Rústica Precio aproximado: 91,20 Euros (IVA incluido) |
Biopharmaceutics is the study of how pharmaceutical properties affect biologic properties and therapeutic usefulness. Biotechnology describes the industry of creating, developing, and marketing products through the manipulation, on a molecular level, of life forms or utilisation of knowledge pertaining to living systems. Biotechnology and Biopharmaceuticals combines these two fields in one coherent textbook, offering the tools for understanding the role biotechnology plays in the discovery and development of therapeutic drugs. | ||
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Medina, Carmen Pharmaceutical compliance Editorial: MARCEL DEKKER, INC. (NEW YORK) 2003, 704 Págs., ISBN: 0-8247-4078-5 Precio aproximado: 237,01 Euros (IVA incluido) |
Lists the necessary steps for meeting compliance requirements during the
drug development process. Presents comprehensive approaches for validating
analytical methods for pharmaceutical applications.
INDICE: Regulatory Submissions Patricia Fritz and Anisa Dhalla. Compliance Requirements During the Drug Development Process Martin D. Hynes. Validation - A New Perspective James Agalloco. Validating Analytical Methods for Pharmaceutical Applications: A Comprehensive Approach Paul A. Winslow and Richard F. Meyer. The Stability Testing Program Maria Geigel. Computer Validation: A Compliance Focus Timothy Horgan and Timothy Carey. Compliance Issues Associated with Cleaning in the Pharmaceutical Industry William E. Hall. The Batch Record: A Blueprint for Quality and Compliance John Fugate. Change Management: A Far Reaching, Comprehensive, and Integrated System Susan Freeman. The Vendor Qualification Program Eizabeth M Troll and Karen L. Hughes. Handling Laboratory and Manufacturing Deviations Robert B. Kirsch. The Internal Audit Program: A Quality Assessment Graham Bunn. Pre-Approval Inspections: The Critical Compliance Path to Success Martin D. Hynes. International Compliance Issues and Trends Alan G. Minsk. Strategic Planning for Compliance and Regulatory Defensiveness Ron Johnson. Unique and Unprecedented Compliance Challenges in the Biologics Area Anne Hoppe and Curtiss Scribner. The Impact of Total Quality Performance on Compliance Carmen Medina, Judith Beach, Valerie Palumbo, and Douglas B. Poucher. Index. |
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Conseil de L'europe. European pharmacopoeia, supplements 4.6, 4.7 and 4.8: pheur04-3SE Editorial: COUNCIL OF EUROPE 2004, 4ª Edic., Cartoné Precio aproximado: 399,36 Euros (IVA incluido) |
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British National Formulary, nº 46, september 2003 Editorial: PHARMACEUTICAL PRESS 2003, 848 Págs., ISBN: 0-85369-556-3, 46ª Edic., Rústica Precio aproximado: 40,60 Euros (IVA incluido), |
Compiled with the advice of clinical experts, this essential reference provides up-to-date guidance on prescribing, dispensing and administering medicines. The BNF details medicines prescribed in the UK, with special reference to their uses, cautions, contraindications, side-effects, dosage and relative costs. Updated every six months, the BNF reflects current best practice as well as legal and professional guidelines relating to the use of medicines. It is intended for use by prescribers in the NHS as well as by pharmacists, nurses and other healthcare professionals. | ||
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Tulunay, F.C.; Orme, M. European collaboration, towards drug development and rational drug therapy: proceedings of the sixth congress of the european association for clinical pharmacology and therapeutics Editorial: SPRINGER VERLAG GmbH & Co.KG 2003, 178 Págs., ISBN: 3-540-14010-7, Rústica Precio aproximado: 93,12 Euros (IVA incluido) |
The Proceedings of the Sixth Congress of the European Association for Clinical Pharmacology and Therapeutics, Istanbul, June 24 - 28, 2003. This volume contains details of the 21 symposia and 3 workshops together with the abstracts from the more than 400 contributions submitted and presented in Istanbul. |
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USP 27-NF 22 U.S. Pharmacopeia and national formulary 2004,
included supplement 1 and 2 Editorial: UNITED STATES PHARMACOPEIA 2003, 1 Págs., ISBN: 1-889788-19-8, 27ª Edic., Cartoné Precio aproximado: 972,40 Euros (IVA incluido) |
As the offcial compendia of acceptable standards for: str engh,
purity, labeling, quality, packaging, storage for drug s and excipients,
the USP and NF are two of the world's trus ted references. These combined
resources, published once eve ry five years, contain over 3.700 monographs
and also provid e standards for devices, diagnostics, nutritional
supplement s, botanicals, and compounded pharmaceuticals. The USP and NF are essentials resources for pharmaceutica l scientists who must comply with official standards and for health care professionals who are concerned about standards for articles used in their practice. The hardcover version of USP 26-NF 21 is a convenient, co mprehensive reference featuring thumbtabs for easy access to the information you need. The hardbound format makes it a r eference you will always want at your side. Inside you will find established standards for the manufacture of medicines and related products. The hardcover edition of USP-NF is your desktop resource for keeping on top of the latest legally recognized drug sta ndards and ensuring the quality of your drug products. Your subscription includes the USP 24-NF 19 publishing in July 19 99 and the Supplement publishing in November 1999. Both will become official in January 2000. |
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Xu, Quanyun A.; Trissel, Lawrence A. Stability-indicating HPLC methods for drug analysis Editorial: AMERICAN PHARMACEUTICAL ASSO- 2003, 690 Págs., ISBN: 1-58212-046-3, 2ª Edic., Cartoné Precio aproximado: 167,50 Euros (IVA incluido), |
Stability-Indicating HPLC Methods for Drug Analysis compiles summaries of stability-indicating HPLC analytical methods that have appeared in the published literature. A first stop for pharmaceutical scientists, analytical chemists, and librarians in the quest for information about the stability of drugs. Co-published by the American Pharmaceutical Association and the Pharmaceutical Press, a division of the Royal Pharmaceutical Society of Great Britain. | ||
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Babine, Robert E.; Abdel-Megui, Sherin S. Protein crystallography in drug discovery Editorial: VERLAG CHEMIE, GmbH. 2003, 280 Págs., ISBN: 3-527-30678-1, Cartoné Precio aproximado: 136,91 Euros (IVA incluido) |
The rational, structure-based approach has become standard in present-day drug design. As a consequence, the availability of high-resolution structures of target proteins is more often than not the basis for an entire drug development program. Protein structures suited for rational drug design are almost exclusively derived from crystallographic studies, and drug developers are relying heavily on the power of this method. Here, researchers from leading pharmaceutical companies present valuable first-hand information, much of it published for the first time. They discuss strategies to derive high-resolution structures for such important target protein classes as kinases or proteases, as well as selected examples of successful protein crystallographic studies. A special section on recent methodological developments, such as for high-throughput crystallography and structural genomics, is also included. A valuable companion for crystallographers involved in protein structure determination as well as drug developers pursuing the structure-based approach for use in their daily work. | ||
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Azzara, Alan J. Prehospital providers guide to medication revised Editorial: MOSBY, C.V. COMPANY (Usa) 2003, ISBN: 0-323-02440-8, Rústica Precio aproximado: 28,89 Euros (IVA incluido) |
This reference of emergency cardiovascular care guidelines reviews the details of the most commonly used prehospital medications in a convenient 'A-to-Z' format, a useful guide for IV fluids, and guidelines for the various routes of administration. Additional features include: a separate chapter on drug abuse including prescription drugs and street drugs; how overdoses, underdosages, side effects, drug allergies, etc will present in the field; and appendices such as common medical abbreviations, common laboratory values, and common prescription drugs. | ||
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Hansten, Phillip D.;Horn, John R. The top 100 drug interactions: a guide to patient management Editorial: HANSTEN AND HORN DRUG INTERAC 2003, ISBN: 0-9674718-4-2, Rústica Precio aproximado: 32,18 Euros (IVA incluido) |
Drs. Hansten and Horn have recently published a pocket-sized drug-drug interaction booklet designed for busy practitioners. It is a small, easy-to-use reference covering the most frequently occurring clinically significant drug-drug interactions. The Top 100 Drug Interactions contains information on approximately 2600 common drug interactions that are likely to be of clinical significance. Object and precipitant drugs are logically grouped to fit the monographs into a convenient pocket-sized booklet. Each interacting drug is listed in the index for easy reference. The focus of the booklet is on drug interaction management options following a brief comment describing the interaction. These options include alternative, non-interacting drugs that could be considered as substitutes for one drug of the interacting drug pair. Advice on how and when to clinically monitor patients receiving potentially interacting drugs is provided. In addition to the interaction monographs, the booklet contains a table listing more than 240 common drugs, the cytochrome P450 enzyme responsible for their metabolism, and any enzymes that the drug is currently known to inhibit or induce. Using this table, the practitioner will be able to predict potential drug-drug interactions that may not as yet have been reported. The Top 100 Drug Interactions is an inexpensive, convenient, authoritative reference on drug-drug interactions that all practitioners should consult when writing a new prescription. | ||
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Winter, Michael E. Basic clinical pharmacokinetics Editorial: LIPPINCOTT WILLIAMS & WILKINS 2003, 511 Págs., ISBN: 0-7817-4147-5, 4ª Edic., Rústica Precio aproximado: 62,02 Euros (IVA incluido) |
Basic Clinical Pharmacokinetics was designed to simplify pharmacokinetics to help busy practitioners understand and visualize basic principles. An easy-to-read, case-study format has made the text a favorite among clinical professors, students, and practitioners. The text provides an introduction to the principles of monitoring drug therapy for those involved in the interpretation of drug levels in a patient care setting. Part One provides a basic review of pharmacokinetic principles. Extensive explanations, graphic illustrations, and detailed algorithms teach the principles of bioavailability, volume of distribution, clearance, elimination rate constant, and half-life. Part Two explains the clinical applications of these principles. Solutions to problems commonly encountered in the practice setting are discussed for specific drugs. Appendices provide commonly used equations and a glossary of pharmacokinetic terms and abbreviations. New to this edition are chapters on tricyclic antidepressants and cyclosporine, an expanded chapter on dialysis, and updated information on choosing equations and interpreting plasma drug concentrations. | ||
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Olsen, June Looby; Giangrasso, Anthony Patrick; Shrimpton, Dolores Medical dosage calculations: international edition Editorial: PRENTICE HALL 2003, 381 Págs., ISBN: 0-13-191132-5, 8ª Edic., Rústica Precio aproximado: 31,15 Euros (IVA incluido) |
Completely revised and updated to include the latest practices and medication, the Eighth Edition maintains its user-friendly structure and offers students a comprehensive yet accessible drug calculation text and workbook. Using the dimensional analysis format, this invaluable resource begins with simple arithmetic and progresses to the most complex drug calculation problem, enabling students to develop the mathematical skills required for medical dosage calculations. With a host of pedagogical aids that includes case studies, self-tests, practice problem sets, and a new Companion Website. This text provides students with both the skills and understanding necessary to master this crucial area of nursing studies. | ||
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Walsh, Gary Biopharmaceuticals: biochemistry and biotechnology Editorial: JOHN WILEY & SONS LIMITED. 2003, 544 Págs., ISBN: 0-470-84327-6, 2ª Edic., Rústica Precio aproximado: 70,14 Euros (IVA incluido) |
The latest edition of this highly acclaimed textbook, provides a comprehensive and up-to-date overview of the science and medical applications of biopharmaceutical products. Biopharmaceuticals refers to pharmaceutical substances derived from biological sources, and increasingly, it is synonymous with 'newer' pharmaceutical substances derived from genetic engineering or hybridoma technology. | ||
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Tecnologia Farmaceutica Industrial, 2 tomos Ed. Prof. Ramon Salazar Macian. Imprenta y distribucion: Romargraf, S.A.. c/ Joventut, 55-57. 08904 L'Hospitalet de Llobregat (Barcelona) Telf: 933345466 Deposito legal: B. 40-263-2003 ISBN 84-931913-5-3 (tomo I) ISBN 84-931913-4-5 (obra completa) |
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Betty L. Gahart, RN and Adrienne R. Nazareno 2004 Intravenous Medications, 20th Edition - A Handbook for Nurses and Allied Health Professionals Mosby Title ISBN:0323024130 Precio aprox: 38 euros |
The 2004 edition of INTRAVENOUS MEDICATIONS, the best-selling intravenous therapy handbook, is updated throughout with hundreds of new drug facts and 10 to 15 new monographs for new IV drugs recently approved by the FDA. More than 350 drug monographs are presented in a clinically useful format. All drugs are indexed by generic and common trade names, as well as by pharmacologic action. Appendixes offer useful information on handling cytotoxic drugs, alternate choices for infrequently used drugs, FDA pregnancy categories, information for patients receiving immunosuppressive agents, and National Cancer Institute common toxicity grading criteria | ||
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A Handbook of Bioanalysis and Drug Metabolism Taylos & Francis ISBN: 0415275202 Precio aproximado: 30 UK Libras |
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John Talbot (Editor), Patrick Waller (Editor) Detection of New Adverse Drug Reactions , 5th edition ISBN: 0-470-84552-X 736 pages Precio aproximado: 150 euros |
This book examines the methods for the early detection of new adverse drug reactions (ADRs), describing and evaluating working methodologies and techniques. It includes the background to ADRs, methodology for the collection of data, laboratory investigations, establishing a side effect profile, pharmacoedpidemiology, management of data and pharmacovigilance and a review of ethical issues. | ||
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Hickey, A Pharmaceutical Inhalation Aerosol Technology Second Edition, Revised and Expanded ISBN: 0-8247-4253-2 288 páginas Precio aprox. 200 euros |
This thoroughly revised and expanded reference provides authoritative
discussions on the physiologic, pharmacologic, metabolic, molecular,
cellular, and physicochemical factors influencing the efficacy and
utilization of pharmaceutical aerosols and analyzes the latest science
and developments in the generation, administration, and characterization
of these compounds—showcasing current clinical applications, the
efficiency and limitations of major aerosol products, and emerging
aerosol therapies impacting the field.
Table of
Contents |
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Lee, J., Obach, R. Drug Metabolizing Enzymes Cytochrome P450 and Other Enzymes in Drug Discovery and Development Marcel Dekker. ISBN: 0-8247-4293-1 |
Cytochrome P450 has a significant bearing on scientific assessments of genetic polymorphism in metabolism, drug-drug interactions and bioavailability of candidate drugs. This text systematizes findings on P450 and similar enzymes, to promote the next generation of safer, more effective drugs. |
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Shayne C
Gad
Safety Pharmacology in Pharmaceutical Development and Approval CRC Press ISBN: 0849313805 Precio aprox: 150 euros |
The Propulsid and Seldane drug disasters could have easily been avoided with more rigorous safety pharmacology studies of these compounds prior to any human clinical trials. Unfortunately, safety pharmacology has been overlooked by all but a few developers. With recent drug withdrawals from the market and the implementation of the International Conference on Harmonization (ICH) guidelines, safety pharmacology will become a more important phase in drug development. Safety Pharmacology in Pharmaceutical Development and Approval spells out the whys and hows of safety pharmacology testing. The book covers the background, history, and concerns that have evolved from lackluster safety pharmacology activities in the past. It details regulatory requirements, provides comprehensive information on study designs, and covers both the required battery of studies and the supplemental, follow-up battery. Until recently, pharmacovigilance has been product-rather than utilization-oriented and often invisible in clinical medicine. It is clear that definitive safety pharmacology standards are needed to combat the increase in adverse reactions seen in the last 20 years. Giving you a head start in this emerging field, Safety Pharmacology in Pharmaceutical Development and Approval addresses how best to implement ICH safety standards and how to integrate pharmacology safety evaluations into existing safety evaluations. |
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Albert Y. Leung, Steven Foster Encyclopedia of Common Natural Ingredients: Used in Food, Drugs, and Cosmetics, 2nd Edition John Wiley & Sons Inc. ISBN: 0-471-50826-8 688 pages Precio aproximado: 190 euros |
Now in its revised and expanded Second Edition, the
Encyclopedia of Common Natural Ingredients stands as the most
authoritative reference for natural ingredients in commercial use. This
new edition addresses the increased interest in natural ingredients over
the past decade, especially in health foods-a category that includes
food products, over-the-counter drugs, and herbal teas. The Encyclopedia encompasses approximately 500 of the most commonly used ingredients, and covers the identification, processing, preparation, and manner of use for each. Following the current demand for products that alleviate stress and other lifestyle-related conditions, this volume emphasizes the drugs and herbal formulations created for those purposes. Expanded to twice the size of its predecessor, the Second Edition updates all the original entries of the first edition, and incorporates many new entries, classifications, references, and a new category, Health Foods/Herbal Teas. The inclusion of a new classification on Chinese medicinal herbs is particularly innovative, offering information that appears here for the first time in English. This classification draws on both classical and modern Chinese medicine and reflects the growing popularity of Chinese herbs in this country and in the rest of the world. This Second Edition of the Encyclopedia of Common Natural Ingredients will be welcomed by chemists, botanists, and product developers in the cosmetic, food, and drug industries, as well as consumers who need an authoritative, up-to-date source of information on this important field. The most authoritative, comprehensive, and up-to-date reference on natural ingredients and their commercial use This greatly expanded and revised edition of the Encyclopedia of Common Natural Ingredients is the only single-source reference devoted to the approximately 500 naturally derived ingredients currently included in a wide range of cosmetics, food items, and drugs. Major features of the Second Edition include: * Accurate information based on reliable research methods * In-depth coverage of each ingredient, including general description, chemical composition, uses and commercial preparations, and synonyms, as well as regulatory status and references * A new category, Health Foods/Herbal Teas, reflecting the latest information on these increasingly popular subjects * An easily accessible alphabetical presentation of the entries according to common names, and cross-referenced to scientific names in the index * Glossary of the most commonly encountered terms used in the botanical industry * A carefully selected general reference list |
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Dev Kambhampati (Editor) Protein Microarray Technology John Wiley & Sons Inc. ISBN: 3527305971 Precio aprox: 105 euros |
This book is the first of its kind in the field of
protein microarrays and addresses novel strategies for constructing
highly functional and biocompatible microarrays for screening proteins. The list of authors consisting of world leading experts provide a roadmap for solving the complex challenges that are currently faced while monitoring protein-protein interactions over a wide range of microarray platforms. In doing so, they also offer a comprehensive overview of microarray surface chemistry, detection technologies, fabrication options for array development, and data analysis of numerous types of protein interactions. Topics covered include: -Types of biomolecular interactions -Surface chemistry -Detection technologies -Spotting technologies -Bioinformatics/data analysis. While primarily intended to serve as a reference for researchers and students embarking on the exciting fields of proteomics, drug discovery and clinical diagnostics, this technology is also expected to potentially impact the areas of food diagnostics, environmental monitoring and national security. |
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Ahuja, Satinder; Alsante, Karen Mills Handbook of isolation and characterization of impurities in pharmaceuticals ACADEMIC PRESS, Inc 2003, 340 Págs., ISBN: 0-12-044982-X Precio aprox. 230 Euros |
The objective of this book is to provide guidance on
isolating and characterizing impurities of pharmaceuticals such as drug
candidates, drug substances, and drug products. It meets the critical
need for a text that provides detailed guidance as to how these
activities are actually carried out in the pharmaceutical industry. Impurity identification is critical in the pharmaceutical industry because the FDA and other regulatory bodies around the world require that impurities in drug substance and drug product at certain levels be isolated and characterized. |
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Easter, Martin C. Rapid microbiological methods in the pharmaceutical industry CRC PRESS LLC 2003, 277 Págs., ISBN: 1-57491-141-4 Precio aprox. 320 Euros |
Provides the details of a range of rapid microbiological methods, their applications, and practical tips regarding validation, established use, and regulatory acceptance.Brings together expert opinion and experience in implementing microbiological methods and their application in the pharmaceutical industry. Covers the origins of methods and current issues facing the requirements of microbiology and its associated test methods. Explores how to seek better, more pragmatic methods for the assessment of microbiological hazards and risks to ensure product and consumer safety. In recent years there has been increased interest in the possibility of rapid microbiological methods offering enhanced potential error detection capabilities. However, these methods raise a number of questions, such as how to validate new methods, will they be accepted by the pharmacopoeias, and, most importantly, how will the regulators respond? Rapid Microbiological Methods in the Pharmaceutical Industry answers these questions and more. Martin Easter and his panel of experts: Describe the range of rapid microbiological methods and their applications, including practical tips, and their status regarding validation, established use, and regulatory acceptance. Explore the origins of current methods and the current issues facing the requirements of microbiology and its associated test methods. Delineate the challenges involved in seeking better and more pragmatic methods for the assessment of microbial hazards and risks to ensure product and consumer safety The book assists you in applying an effective system to assess the real microbiological hazards and, hence, quantify realistic risks. Additionally, it provides monitoring methods that will deliver meaningful, useful data for effective decision making in manufacturing, quality assurance, and product safety. The expert and authoritative information in Rapid Microbiological Methods in the Pharmaceutical Industry will help you find better solutions to ensuring the microbiological safety of pharmaceutical products. | ||
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Lee, Chi-Jen; Lee, Lucia H.; Lu, Cheng-Hsiung Development and evaluation of drugs: from laboratory through licensure to market CRC PRESS LLC 2003, 241 Págs., ISBN: 0-8493-1401-1, 2ª Edic. Precio aproximado: 260 Euros |
Updates and expands on the information provided in the previous edition. Discusses hot topics such as genome structures, rational drug design, good manufacturing practices, and more. Covers bioavailability and bioequivalence and their importance to drug manufacturers. Provides detailed regulatory information for critical phases of drug development pre-licensure, and post-marketing (Phase IV) studies. Since its initial publication in 1993, Development and Evaluation of Drugs from Laboratory through Licensure to Market has been used as a textbook and reference for scientists in biomedical research, industry, and regulatory agencies. Updated and expanded, this second edition examines recent advances in scientific and regulatory approaches as well as changes in the way in which drugs are discovered, developed, and evaluated. The information provided outlines critical steps beginning from drug discovery in the laboratory to licensure and approval for market. Biomedical research is an intrinsically changing and evolving field. A more direct strategy for drug discovery has gradually replaced random screening of natural products. More rapid identification of key molecular structures for new drug candidates and characterization of biomolecules including proteins, polysaccharides, and nucleic acids are now possible. The ability to chemically modify cell surfaces and carbohydrate linkages has facilitated designs of the next generation of new drugs. Thoroughly discussing these issues and more, Development and Evaluation of Drugs from Laboratory through Licensure to Market, Second Edition focuses on the latest developments in the science and regulation of bringing new drugs to market, including activities of the International Commission on Harmonization. | ||
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Revision of the pharmaceutical affairs regulations 2002 Editorial: YAKUJI NIPPO LTD. 2003, 80 Págs., ISBN: 4-8408-0726-4 Precio aprox.: 95 Euros |
Safety measures pertaining to medical devices. Safety measures for biological products in accommodation of the century of 'Bio and genomic technologies'. Post-marketing safety measures and the system for approval and license for drugs and medical devices. | ||
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Abraham, John; Lawton Smith, Helen Regulation of the pharmaceutical industry MACMILLAN DISTRIBUTION, LTD. 2003, 278 Págs., ISBN: 0-333-79044-8 Precio aprox: 108,22 Euros |
How are pharmaceutical technologies developed and controlled in our societies? To what extent should the availability of these technologies be determined by scientific experts, a democratic state, the interests of final users, or ethical principles? This unique collection brings together the work of social scientists, ethicists, lawyers and policy analysts on regulation, ethics and innovation in the pharmaceutical industry. Regulatory systems and their implications for public health in North America, Europe and developing countries are discussed, including case studies of norplant, interferon and anti-fertility vaccines. | ||
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Bontemps, Florence Consejos en la oficina de farmacia: guía práctica ARS MEDICA 2003, ISBN: 84-9751-005-4, Carpeta Anillas Precio aprox: 185,00 Euros (IVA incluido) |
INDICE: LAS GRANDES AREAS DEL CONSEJO FARMACEUTICO:
Dermatología. Dietética. Flebología. Gastroenterología. Ginecología.
Neuropsiquiatría. Otorrinolaringología y oftalmología. Pediatría.
Reumatología y traumatología. Viajes y vacaciones. FICHAS PRACTICAS:
Acné. Aerosoles. Aftas. Alopecia. Amigdalitis. Analgésicos orales para
el adulto de dispensación si receta. Anorexia del anciano. Anorexia
nerviosa. Ansiedad. Anticonceptivos de urgencia. Antisépticos El reconocimiento del farmacéutico como profesional sanitario depende del servicio que ofrece, constituyendo un aspecto básico el consejo farmacéutico, que debe prestar con el máximo de competencia y de eficacia, es decir, poder dar la respuesta más exacta y oportuna a la duda planteada. Este libro trata situaciones frecuentes a las que se enfrenta el farmacéutico en aspectos relativos a curas, patologías y dispensación de medicamentos. La obra ofrece el farmacéutico un repaso a los conocimientos científicos así como las leyes fundamentales relativas a su labor diaria en la oficina de farmacia. Toda esta información se ofrece en prácticas y manejables fichas técnicas. Incluye más de 120 fichas clasificadas por orden alfabético para poder orientar fácilmente al profesional y sus ayudantes |
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Gennaro, Alfonso Remington. Farmacia, tomo 1 PANAMERICANA 2003, 1406 Págs., ISBN: 84-7903-661-3, 20ª Edic. Precio aprox.: 90,00 Euros |
Cada capítulo refleja los nuevos conocimientos en este
campo y se añaden diez nuevos sobre práctica farmacéutica. Varios
temas como el referido a medicina alternativa han sido ampliados. Se han
seleccionado las monografías de las drogas, así se presenta la
información útil para los especialistas de forma ampliada. Otros temas han sido suprimidos para evitar material de referencia excesivo, con la finalidad de destacar los principios de instrucción y aprendizaje mientras se retiene el material de consulta esencial. Cuenta con la colaboración de autores procedentes de 134 universidades diferentes, y de la industria pública y privada. Un libro de texto y una obra de referencia imprescindible para farmaceúticos, bioquímicos, médicos y otros profesionales de las ciencias farmaceúticas y médicas. INDICE: Parte 1: Orientación. Parte 2: Ciencia farmacéutica. Parte 3: Química farmacéutica. Parte 4: Pruebas, análisis y control farmacéuticos. Parte 5: Farmacia industrial. Parte 6: Farmacodinámica. |
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Remington, Joseph P. Ciencia y práctica de la farmacia, vol. 1 Editorial: PANAMERICANA 2003, 1500 Págs., ISBN: 950-06-5081-9, 20ª Edic., Cartoné Precio aprox: 90,00 Euros |
Se ha producido una metamorfosis prudente y planificada
de la obra que implica la reorganización, reducción o ampliación de
algunas áreas. - Se han seleccionado las monografías de las drogas, y
la mayor parte de la información sobre dosis y dosificación ha sido
suprimida de las monogtrafías de las drogas individuales. - Los
comentarios generales que preceden a las clases individuales de drogas
han sido ampliados para que brinden una cobertura extensa de cada clase.
De este modo, la información útil para el especialista en drogas se
presenta en un formato ampliado, en lugar de ofrecer una masa abrumadora
de datos que, si se aprenden de moemoria, pueden confundirse u
olvidarse. - Se ha suprimido la lista de los fabricantes de cada droga
(oficiales, genéricos o ambos). - Cada capítulo ha sido revisado
cuidadosamente para reflejar los nuevos conocimientos en este campo y se
han agregado diez nuevos sobre práctica farmacéutica. Varios temas,
como el referente a medicina alternativa, fueron ampliados. - Cuenta con
la colaboración de autores procedentes de 34 diferentes universidades y
de la industria pública y privada.
INDICE: Parte 1 Orientación. Parte 2 Ciencias farmacéutica. Parte 3 Química farmacéutica Parte 4 Pruebas, análisis y control farmacéuticos Parte 5 Industria farmacéutica Parte 6 Farmacodinámica Parte 7 Agentes farmacéuticos y medicinales Parte 8 Práctica de la farmacia Parte 8A Administración de la farmacia Parte 8B Nociones fundamentales de la práctica de la farmacia Parte 8C Cuidados del paciente Apéndices Glosario e Indice |
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Remington, Joseph P. Ciencia y práctica de la farmacia, vol. 2 PANAMERICANA 2003, 1500 Págs., 20ª Edic., Cartoné Precio aprox: 90,00 Euros |
Se ha producido una metamorfosis prudente y planificada
de la obra que implica la reorganización, reducción o ampliación de
algunas áreas. - Se han seleccionado las monografías de las drogas, y
la mayor parte de la información sobre dosis y dosificación ha sido
suprimida de las monogtrafías de las drogas individuales. - Los
comentarios generales que preceden a las clases individuales de drogas
han sido ampliados para que brinden una cobertura extensa de cada clase.
De este modo, la información útil para el especialista en drogas se
presenta en un formato ampliado, en lugar de ofrecer una masa abrumadora
de datos que, si se aprenden de moemoria, pueden confundirse u
olvidarse. - Se ha suprimido la lista de los fabricantes de cada droga
(oficiales, genéricos o ambos). - Cada capítulo ha sido revisado
cuidadosamente para reflejar los nuevos conocimientos en este campo y se
han agregado diez nuevos sobre práctica farmacéutica. Varios temas,
como el referente a medicina alternativa, fueron ampliados. - Cuenta con
la colaboración de autores procedentes de 34 diferentes universidades y
de la industria pública y privada.
INDICE: Parte 1 Orientación. Parte 2 Ciencias farmacéutica. Parte 3 Química farmacéutica Parte 4 Pruebas, análisis y control farmacéuticos Parte 5 Industria farmacéutica Parte 6 Farmacodinámica Parte 7 Agentes farmacéuticos y medicinales Parte 8 Práctica de la farmacia Parte 8A Administración de la farmacia Parte 8B Nociones fundamentales de la práctica de la farmacia Parte 8C Cuidados del paciente Apéndices Glosario e Indice |
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López Piñero, José María Atlas histórico de la ilustración anatómica (cd-rom): desde el renacimiento al siglo XX FAXIMIL, Edicions Digitals 2003, Software, ISBN: 84-931851-8-3 Precio aprox: 58,00 Euros |
El Atlas Histórico de la Ilustación Anatómica recopila un total de 461 láminas facsimilares pertenecientes al período que abarca del Renacimiento al siglo XX. La selección ha sido realizada por el Catedrático de Historia de la Medicina de la Universitat de ValÞncia José María López Piñero y las ilustraciones, procedentes de todos los países, han sido seleccionadas por su importancia desde un triple criterio: científico, artístico y técnico (gráfico). Se incluye también un catálogo técnico de las ilustraciones e índices onomásticos (anatomistas, dibujantes y grabadores) y de materias. La aplicación permite la búsqueda en los contenidos del catálogo y los índices. Igualmente se incluyen los estudios: El saber anatómico y la imagen del cuerpo humano desde el Renacimiento al siglo XX por José María López Piñero y Las técnicas del arte gráfico al servicio de la anatomía (siglos XVI-XIX) por Felipe Jerez Moliner de la Universitat de ValÞncia. Esta edición es exclusiva para usuarios del sistema operativo Windows. | ||
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Chow, Shein-Chung Encyclopedia of biopharmaceutical statistics MARCEL DEKKER, INC. (NEW YORK) 2003, ISBN: 0-8247-4262-1, 2ª Edic. Precio aproximado 400 Euros |
Remaining on the cutting-edge of this rapidly evolving field, this unequaled resource has expanded more than 70% of its original entries to review amendments to regulatory requirements and recently developed statistical methods impacting the drug review/approval process and biopharmaceutical research and development. Alerts specialists to current standards and best practices in clinical, laboratory, manufacturing, and statistical design, investigation, and analysis. Eclipsing any other competing source, the Second Edition offers more than 5800 references, 150 contributors, and nearly 3000 equations, tables, and figures for thorough exploration of emerging technologies, concepts, and trends vital to the biopharmaceutical industry. | ||
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Dictionnaire Vidal 2003 O.V.P. -OFFICE DE VULGARISA- 2003, 2584 Págs., 79ª Edic. Precio aproximado: 250 Euros |
Avec 5780 médicaments et 4018 produits de parapharmacie référencés
pour cette 79e édition, le Dictionnaire VIDAL est l'ouvrage
indispensable aux professionnels de Santé au cours de leur pratique
quotidienne. Chaque monographie reprend l'information officielle du Résumé
des Caractéristiques du Produit (RCP), issu de l'Agence Française de Sécurité
Sanitaire des Produits de Santé (AFSSAPS). Consultable facilement Ó partir d'une classification alphabétique, la monographie organisée en rubriques apporte une information complÞte sur le médicament. Des classifications spécifiques identifiées par des sections de couleur (bleue, jaune, rouge, blanche, saumon et verte) facilitent la recherche d'un médicament ou d'un produit. |
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Jucker, Ernst Progress in drug research, vol. 60 BIRKHAUSER VERLAG. 2003, 364 Págs., ISBN: 3-7643-6987-6 Precio aproximado: 350 Euros |
Progress in Drug Research is a prestigious book series which provides extensive expert-written reviews on a wide spectrum of highly topical areas in current pharmaceutical and pharmacological research. Founded in 1959 by its Editor Ernst Jucker, the series has moved from its initial focus on medicinal chemistry to a much wider scope. Today it encompasses all fields concerned with the development of new therapeutic drugs and the elucidation of their mechanisms of action, reflecting the increasingly complex nature of modern drug research. Invited authors present their biological, chemical, biochemical, physiological, immunological, pharmaceutical, toxicological, pharmacological and clinical expertise in carefully written reviews and provide the newcomer and the specialist alike with an up-to-date comprehensive list of prime references. Each volume (no. 1-60) of Progress in Drug Research contains fully cross-referencing indices which link the books together, forming a virtually encyclopaedic work. The series thus serves as an important, time-saving source of information for researchers concerned with drug research and all those who need to keep abreast of the many recent developments in the quest for new and better medicines. | ||
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British pharmacopoeia 2003 HER MAJESTY'S STATIONERY 2003, ISBN: 0-11-322595-4 Precio aproximado: 1.600 Euros |
The only authoritative collection of standards for UK medicinal substances and an essential reference point for everyone involved in their research, development and manufacture. With UK and European standards constantly changing, only the BP 2003 can assure you of complete compliance within the United Kingdom. It is supplied in three formats, a boxed five volume set for quick reference, a CD-ROM for quick and easy searches and a comprehensive, searchable website, acopoeia including supplement 4.5 ere in the world by password. Incorporates the requirements of the 4th edition of the European Pharmacopoeia including supplement 4.5 CD-ROM contains the full text of the BP2003 and British Approved Names 2003, with search capability Comprehensive, searchable website that is updated daily and accessible by password | ||
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Vademécum internacional 2002 (PDA) Editorial: MEDICON 2002, Software Precio aproximado: 90 Euros |
VADEMECUM INTERNACIONAL en PDA está disponible para los sistemas operativos Windows CE 2000 y CE 2002 y Palm. VADEMECUM INTERNACIONAL en PDA permite la consulta de medicamentos a través de Clasificación Alfabética, Indicaciones Terapéuticas, Laboratorios y Principios Activos. Para cada medicamento seleccionado podrá consultar la Ficha Técnica y los Módulos de soporte (Uso en embarazo, lactación, pediatría, geriatría; Interacción con medicamentos, alimentos pruebas de laboratorio y deporte; y Contraindicaciones). | ||
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Practice of Medicinal Chemistry, Second Edition May 2003, Hardbound, 736 pp, ISBN: 0-12-744481-5 (Academic Press) Precio aproximado: $174.95 / £115.95 |
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PROGRESS IN MEDICINAL CHEMISTRY, Volume 41 Edited by F.D. King and A.W. Oxford |
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Ahuja, S. HANDBOOK OF ISOLATION AND CHARACTERIZATION OF IMPURITIES IN PHARMACEUTICALS. Academic Press, Inc |
Filling the need for a reference text on the complex process of isolating and characterizing process-related impurities and degradation products, this volume describes the techniques and technologies used to meet critical industry regulatory requirements. | ||
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Brittain, Harry G. |
Although the official compendia define a drug substance as to identity, purity, strength, and quality, they normally do not provide other physical or chemical data, nor do they list methods of synthesis or pathways of physical or biological degradation and metabolism. Such information is scattered throughout the scientific literature and the files of pharmaceutical laboratories. Analytical Profiles of Drug Substances and Excipients, brings the latest information together in one source. | ||
| Rowe, Raymond C. Sheskey, Paul J. Weller, Paul J. Handbook of pharmaceutical excipients: cd-rom + book PHARMACEUTICAL PRESS 2003, 864 Págs., ISBN: 0-85369-537-7, 4ª Edic. |
The Handbook of Pharmaceutical Excipients
is internationally recognised as the authoritative source of information
on pharmaceutical excipients. Written by over 120 pharmaceutical scientists
expert in pharmaceutical formulation or excipient manufacture, this
new, third edition of the Handbook contains 215 excipient monographs.
Several new monographs have been added and all existing monographs
completely revised and updated. |
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| Clarke's analysis of drugs and poisons
(cd-rom) Moffat, Anthony C. PHARMACEUTICAL PRESS 2003, 3ª Edic ISBN: 0-85369-501-6 |
This practical manual and standard reference work provides an authoritative source of analytical data for drugs and related substances. The 18 chapters in Part 1 each describe a particular analytical technique or allied subject and are written by well-known experts in the field. Part 2 comprises monographs with analytical and toxicological data for more than 1300 drugs and related substances. Part 3 contains 66 indexes of analytical data for chromatography, spectrophotometry, and mass spectrometry, together with indexes of molecular weight and melting point and Part 4 consists of descriptions of reagents used in analytical procedures in Parts 1 and 2. An exhaustive 48 page general index of nearly 12,500 entries concludes the work. This book is intended for scientists faced with the difficult problem of identifying an unknown drug in a pharmaceutical product, in a sample of tissue or body fluid from a living patient or in postmortem material. Clarke's Isolation and Identification of Drugs is an essential requirement for all forensic and crime laboratories, toxicologists, clinical and analytical chemists, pathologists, poison information centres and clinical pharmacology departments. Part 1 consists of approximately 30 chapters on forensic toxicology and pharmaceutical analysis written by leading experts from Europe, North America and Australia. It includes chapters on: Hospital Toxicology, Alcohol and Drugs in Driving, Forensic Toxicology, Drugs in Saliva, Hair analysis, Natural toxins, Immunoassays, Infra-red Spectrophotometry, Mass Spectrometry, Emergin techniques, etc. Part 2 consists of structured drug summaries for appromiately 1800 pharmaceuticals, drugs of abuse, pesticides and other substances. Part 3 consists of various indexes used to identify an unknown substance | ||
| Normas de correcta fabricación medicamentos
de uso humano y medicamentos veterinarios MINISTERIO DE SANIDAD. 2002, 250 Págs., ISBN: 84-7670-599-9 Precio aproximado: 9,20 Euros |
En 1991, la Comisión de las Comunidades Europeas adoptó dos Directivas por las que se establecen los principios y directrices de las Normas de correcta fabricación para los medicamentos. La primera se refiere a los medicamentos de uso humano (Directiva 91/356/CEE) y la segunda a los medicamentos veterinarios (Directiva 91/412/CEE). La presente guía de buenas prácticas de fabricación contiene directrices detalladas establecidas de acuerdo con estos principios. Esta guía se utilizará para evaluar las solicitudes de autorización de fabricación, y será igualmente utilizada como base para las inspecciones de los fabricantes de medicamentos. | ||
| Stonier, Peter D. Careers in the pharmaceutical industry JOHN WILEY & SONS, LTD.(2ª) 2003, 304 Págs., 2nd ed ISBN: 0-470-84328-4 |
In recent years, many factors have combined to change the operating environment of the international pharmaceutical industry leading to greater specialization and sophistication. This new edition gives an update of the different opportunities in drug discovery and development and the scientific, medical or other specialist training needed to accomplish them. The scope of this edition has been broadened to encompass all major roles, including marketing and sales.. Examines all major careers in the pharmaceutical industry. Explains how to pursue specific positions. Deals with issues in changing jobs within the industry | ||
| Carroll, Pamela Fitzgerald, Kevin Model organisms in drug discovery JOHN WILEY & SONS, LTD.(2ª) 2003, 320 Págs., ISBN: 0-470-84893-6, |
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| A to Z drug facts FACTS & COMPARAISON, INC. 2003, 2200 Págs., 4ª Edic ISBN: 1-57439-132-1 |
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| Jones, Rhonda M. Rospond, Raylene M. Patient assessment in pharmacy practice Editorial: WILLIAMS & WILKINS. 2002, 690 Págs., ISBN: 0-683-30256-6, |
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| Lacy, Charles F. Armstrong, Lora L. Goldman, Morton P. Lance, Leonard L. Drug information handbook LEXI-COMP INCORPORATED 2003, 2029 Págs., 11ª Edic. ISBN: 1-59195-048-1 |
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| Goodman, Louis Sanford Goodman and Gilman, las bases farmacológicas de la terapeutica McGRAW-HILL 2003, ISBN: 970-10-3879-7, 10ª Edic. |
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| Bachmann, Kenneth A. Drug interactions handbook: the new standard for drug and herbal interactions LEXI-COMP INCORPORATED 2003, 700 Págs., ISBN: 1-59195-015-5 |
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| Encyclopedia of clinical pharmacy DIpiro, Joseph T. MARCEL DEKKER, INC. (NEW YORK) 2002, 800 Págs., ISBN: 0-8247-4240-0 Precio apox: 430,82 Euros |
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| Pharmaceutical process validation Nash, Robert A., Wachter, Alfred H. MARCEL DEKKER, INC. (NEW YORK) 2003, 912 Págs., ISBN: 0-8247-0838-5, 3ª Edic. Precio aprox.: 302,21 Euros |
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| Affinity capillary electrophoresis in
pharmaceutics and biopharmaceutics Neubert, Reinhard H. H., Rüttinger, Hans-Hermann MARCEL DEKKER, INC. (NEW YORK) 2003, 384 Págs., ISBN: 0-8247-0951-9 Precio aprox: 225,06 Euros |
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| Simulation for designing clinical trials:
a pharmacokinetic-pharmacodynamic modeling perspective Kimko, Hui C., Duffull, Stephen B. MARCEL DEKKER, INC. (NEW YORK) 2002, 416 Págs., ISBN: 0-8247-0862-8 Precio aprox. 225,06 Euros |
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| Ophtalmic drug delivery systems Mitra, Ashim K. MARCEL DEKKER, INC. (NEW YORK) 2003, 704 Págs., ISBN: 0-8247-4124-2, 2ª Edic. Precio aprox.: 289,36 Euros |
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| Foundations of pharmacokinetics Rescigno, Aldo PLENUM PUBLISHING CORPORATION 2002, 242 Págs., ISBN: 0-306-47704-1, Cartoné Precio aprox.: 145,60 Euros |
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| Modern pharmaceuticals Banker, Gilbert S.; Rhodes, Christopher T. MARCEL DEKKER, INC. (NEW YORK) 2002, 864 Págs., ISBN: 0-8247-0674-9, 4ª Edic. Precio aprox. 260,18 Euros |
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| Pharmaceutical biotechnology: an introduction
for pharmacists and pharmaceutical sicentists Crommelin, Daan J.A.; Sindelar, Robert D. TAYLOR AND FRANCIS 2002, 425 Págs., ISBN: 0-415-28501-1, 2ª Edic Precio aprox. 66,41 Euros |
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| Pharmaceutical care: insights from community
pharmacists Tindall, William N.; Millonig, Marsha K. TECHNOMIC PUBLISHING CO. INC. 2002, 192 Págs., ISBN: 1-56676-953-1 Precio aprox. 83,36 Euros |
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| La medicina en la historia López Piñero, José María ESFERA DE LOS LIBROS, S.L 2002, 717 Págs., ISBN: 84-9734-089-2 Precio aprox. 36,00 Euros |
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| American Drug Index 2003 Billups, Norman F.; Billups, Shirley M. FACTS & COMPARAISON, INC. 2002, 1077 Págs., ISBN: 1-57439-133-X, 47ª Edic. Precio aprox. 99,16 Euros |
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| Facts & Comparisons. Drug facts and
comparisons 2003 FACTS & COMPARAISON, INC. 2003, 2499 Págs., ISBN: 1-57439-135-6, 57ª Edic Precio aprox. 275,45 Euros |
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| Interacciones medicamentosas Lépori, Luis Raúl ARS MEDICA 2002, 706 Págs., ISBN: 987-1114-01-X Precio aprox. 48,88 Euros |
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| Industrial pharmaceutical biotechnology Klefenz, Heinrich VERLAG CHEMIE, GmbH. 2002, 350 Págs., ISBN: 3-527-29995-5 Precio aprox. 150,52 Euros (IVA incluido) |
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| USP 26-NF 21 U.S. Pharmacopeia and National
Formulary 2003 Included supplement 1 and 2 Editorial: USPC, Inc. 2002, 26ª Ed., |
NEW 2003 ANNUAL EDITION. FDA-ENFORCEABLE JAN 1, 2003. AVAILABLE NOV 2002. USP–NF supports your quality, compliance, and excellence. The new annual edition, USP 26–NF 21, has more than 4,000 monographs featuring the latest standards for prescription and non-prescription drug ingredients and dosage forms, dietary supplements, medical devices, and other healthcare products. The monographs include descriptions, requirements, tests, analytical procedures, and acceptance criteria. |
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| Lee, Mike S. LC/MS applications in drug development Editorial: JOHN WILEY & SONS, LTD.(2ª) 2002, 243 Págs., ISBN: 0-471-40520-5 126,93 Euros (IVA incluido) |
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| Moral Gadeo, Juan Elaboración de productos farmaceúticos y parafarmaceúticos Editorial: MERIAL Editorial, S.L. 2002, ISBN: 84-96948-33-9, Rústica 20,00 Euros (IVA incluido) |
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| Who. WHO model formulary Editorial: ORGANIZACION MUNDIAL DE LA (D 2002, 516 Págs., ISBN: 92-4-154559-3 33,13 Euros (IVA incluido) |
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| Estrade, Marie-Noëlle Consejos de cosmetología Editorial: ARS MEDICA 2002, 288 Págs., ISBN: 84-9751-006-2, Rústica 35,50 Euros (IVA incluido) |
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| McCormick, Kate Quality: pharmaceutical engineering series Editorial: BUTTERWORTH-HEINEMANN 2002, 274 Págs., ISBN: 0-7506-5113-X, Cartoné 238,42 Euros (IVA incluido) |
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| Banker, Gilbert S., Rhodes, Christopher T. Modern pharmaceuticals 2002, 864 Págs., ISBN: 0-8247-0674-9, 4ª Edic., 303,98 Euros (IVA incluido) |
Completely revised and expanded throughout. Presents a comprehensive, integrated, sequenced approach to drug dosage formulation, design, and evaluation. Identifies the pharmacodynamic and physicochemical factors influencing drug action through various routes of administration | ||
| Sweetman, Sean Martindale: The complete drug reference 2002, 2300 Págs., 33ª Edic. 395,20 Euros (IVA incluido) |
CARACTERISTICAS: Encyclopaedic
facts about drugs and medicines. 5,300 drugmonographs. 95,000 preparations. 32,000 references. 7,800 manufacturers. Synopses of disease treatments. Enables identification of medicines, the local equivalent and the manufacturer. Includes herbal medicines. NOVEDADES: New for the thirty-third edition: Every entry thouroughly re-evaluated. Over 175 new drugs. Chapters rearranged to reflect current therapeutic practice. Preferential use of Recommended/International Names (rINN) for monograph titles. Clearer presentation of physical chracteristics for pharmacopoeial substances. Greater world-wide coverage of proprietary preparations. INDICE: Part 1- Monographs on drugs and ancillary substances Contains 51 chapters, each dealing with a group of drugs that has similar uses or actions. Part 2 - Supplementary drugs and other substances Consists of more than 800 monogpahs on drugs not easily classified and much more. Part 3 - Preparations Lists the composition of more than 95,000 proprietary preparations. Indexes; Directory of Manufacturers; General Index. |
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| Edwards, Rodger Pharmaceutical engineering series, 12 volume set 2002, ISBN: 0-340-75889-9 2.223,64 Euros (IVA incluido) |
INDICE: Part One: Foundation: Volume 1: Safety, Health & Environment . Volume 2: Introduction to Pharmaceutical Technology & Microbiology . Volume 3: Quality Assurance and Regulatory Issues . Part Two: Buildings and Services: Volume 4: Facility Design, Construction and Finishes . Volume 5: Environmental Systems - HVAC, Effluent and Containment . Volume 6: Services and Utilities - Steam, Water and Gases . Part Three: Equipment, Facilities and Layout: Volume 7: Liquid Products, Parenterals, Sterilisation . Volume 8: Solid Dosage Forms . Volume 9: Packaging - Design and Operations . Part Four: Process Operations: Volume 10: Manufacturing Operations and Involvement . Volume 11: Process Control, Automation and Data Management . Volume 12: Plant, Process and Computer Systems Validation. | ||
| Ubramanian, G. Manufacturing of gene therapeutics: methods, processing, regulation and validation 2001, 364 Págs., ISBN: 0-306-46680-5 147,37 Euros (IVA incluido). |
INDICE: Somatic Gene Therapy, Paradigm Shift or Pandora's Box: A Perspective on Gene Therapy; M. Lawler. Gene Therapy for Cancer: Deceiving the Malignant Cell; M. Lawler. Gene Self-Assembly (GENSA): Facilitating the Construction of Genes and Vectors; C.P. Hodgson. Gene Expression; J. Kaur, et al. Tumour Genotype and Response to Cytotoxic Gene Therapy; P.T. Daniel, et al. Protein Binding Matrices: Tools for Phenol-free Cloning and Vector Assembling; V.I. Evtushenko. Gene Transfer into Eukaryotic Cells; M. Weber. Plasmid DNA Manufacturing; M. Schleef, et al. Quality Assurance and Quality Control for Viral Therapeutics; S.S. Kuwahara. Analytical Assays to Characterise Adenoviral Vectors and Their Applications; E. Lehmberg, et al. Validation of Gene Therapy Manufacturing Processes: A Case Study for Adenovirus Vectors; D. Vacante, et al. Gene Delivery; A. Anand. Regulatory Issues in Gene Therapy. Good Science -- Good Sense; N. Chew, J.A. Cavagnaro. Regulatory Aspects in Gene Therapy: Special Highlights on European Regulation; O. Cohen-Haguenhauer. Regulatory Issues for Process Development and Manufacture of Plasmids Under Contract; J.M. Jenco. Risk Assessment in Gene Therapy; A. Anand, S.K. Arora. Index | ||
| Koda-Kimble, Mary Anne Young, Lloyd Yee Applied therapeutics: the clinical use of drugs 2001, 3008 Págs., ISBN: 0-7817-3137-2, 7ª Edic., , Cartoné 189,85 Euros (IVA incluido) |
INDICE: I. GENERAL PRINCIPLES 1. Assessment of Therapy and Pharmaceutical Care 2. Interpretation of Clinical Laboratory Tests 3. Herbs and Other Dietary Supplements 4. Drug Allergy and Anaphylaxis 5. Managing Acute Drug Toxicity II. GENERAL CARE 6. Nausea and Vomiting 7. Pain 8. Perioperative Care 9. Acid-Base Disorders 10. Fluid and Electrolyte Disorders III. CARDIAC AND VASCULAR DISORDERS 11. Dyslipidemias 12. Essential Hypertension 13. Peripheral Vascular Disorders 14. Thrombosis 15. Ischemic Heart Disease 16. Myocardial Infarction 17. Heart Failure 18. Cardiac Arrhythmias 19. Hypertensive Emergencies 20. Shock IV. PULMONARY DISORDERS 21. Asthma 22. Chronic Obstructive Pulmonary Disease 23. Acute and Chronic Rhinitis 24. Drug-Induced Pulmonary Disorders V. GASTROINTESTINAL DISORDERS 25. Upper Gastrointestinal Disorders 26. Inflammatory Bowel Disease 27. Alcoholic Cirrhosis 28. Adverse Effects of Drugs on the Liver VI. RENAL DISORDERS 29. Acute Renal Failure 30. Chronic Renal Failure 31. Renal Dialysis 32. Dosing of Drugs in Renal Failure 33. Solid Organ Transplantation VII. NUTRITION ISSUES 34. Adult Enteral Nutrition 35. Adult Parenteral Nutrition VIII. SKIN DISORDERS 36. Dermatotherapy 37. Acne 38. Psoriasis 39. Photosensitivity and Burns IX. ARTHRITIC DISORDERS 40. Gout and Hyperuricemia 41. Rheumatic Disorders 42. Connective Tissue Disorders: The Clinical Use of Corticosteroids X. WOMEN,S HEALTH 43. Contraception 44. Obstetrics 45. Teratogenicity and Drugs in Breast Milk 46. Gynecological Disorders XI. ENDOCRINE DISORDERS 47. Thyroid Disorders 48. Diabetes Mellitus XII. EYE DISORDERS 49. Eye Disorders XIII. NEUROLOGICAL DISORDERS 50. Headache 51. Parkinson's Disease 52. Seizure Disorders 53. Cerebrovascular Disorders XIV. INFECTIOUS DISEASES 54. Principles of Infectious Diseases 55. Antimicrobial Prophylaxis for Surgical Procedures 56. CNS Infections 57. Endocarditis 58. Respiratory Tract Infections 59. Tuberculosis 60. Infectious Diarrhea 61. Intra-Abdominal Infections 62. Urinary Tract Infections 63. Sexually Transmitted Diseases 64. Osteomyelitis/Septic Arthritis 65. Traumatic Skin and Soft Tissue Infections 66. Infections in Neutropenic Patients 67. Pharmacotherapy of Human Immunodeficiency Virus (HIV) 68. Opportunistic Infection to HIV Patients 69. Fungal Infections 70. Viral Infections 71. Viral Hepatitis 72. Parasitic Infections 73. Tick-Borne Disease XV. PSYCHIATRIC DISORDERS 74. Anxiety Disorders 75. Sleep Disorders 76. Schizophrenia 77. Mood Disorders I: Major Depressive Disorders 78. Mood Disorders II: Bipolar Disorders 79. Psychiatric Disorders in Children, Adolescents, and People with Developmental Disabilities 80. Secondary Neuropsychiatric Disorders 81. Eating Disorders/Weight Management XVI. SUBSTANCE ABUSE 82. Psychoactive Substance Use Disorders 83. Alcohol Abuse XVII. HEMATOPOIETIC DISORDERS 84. Anemias 85. Drug-Induced Blood Disorders XVIII. NEOPLASTIC DISORDERS 86. Neoplastic Disorders and Their Treatment: General Principles 87. Adverse Effects of Chemotherapy 88. Hematological Malignancies 89. Solid Tumors 90. Hematopoietic Cell Transplantation XIX. PEDIATRICS 91. Pediatric Considerations 92. Neonatal Therapy 93. Immunizations 94. Pediatric Infectious Diseases 95. Pediatric Nutrition 96. Cystic Fibrosis XX. GERIATRIC THERAPY 97. Geriatric Rehabilitation and Drug Use 98. Geriatric Dementias 99. Geriatric Urological Disorders. | ||
| Belon, J.P. Consejos en la farmacia 2002, 440 Págs., ISBN: 84-458-1090-1, Rústica 42,00 Euros (IVA incluido) |
INDICE: I. DISPENSACIÓN DE MEDICAMENTOS. 1. El farmacéutico ante la prescripción médica. 2. El farmacéutico frente a una dispensación sin receta. 3. Consejos generales para la dispensación de medicamentos. II. ENFERMEDADES CARDIOVASCULARES. 4. Hipertensión arterial. 5. Insuficiencia cardíaca. 6. Palpitaciones. 7. Dolor torácico. 8. Insuficiencia venosa. III. ENFERMEDADES PULMONARES. 9. Tos. 10. Bronquitis aguda. 11. Bronquiolitis. 12. Asma. IV. ENFERMEDADES HEPÁTICAS, GASTROINTESTINALES Y RECTALES. 13. Dispepsia. 14. Gastritis. 15. Epigastralgia. 16. Indigestión. 17. Reflujo gastroesofágico. 18. Úlcera gastroduodenal. 19. Diarrea. 20. Estreñimiento. 21. Hemorroides. V. ENFERMEDADES INFECCIOSAS Y PARASITARIAS. 22. Resfriado. 23. Gripe. 24. Meningitis. 25. Hepatitis. 26. Enfermedades infantiles. VI. ENFERMEDADES EN OTORRINOLARINGOLOGÍA. 27. Rinitis. 28. Laringitis. 29. Anginas. VII. ENFERMEDADES ESTOMATOLÓGICAS. 30. Aftas bucales. 31. Gingivitis. 32. Estomatitis. 33. Herpes labial recurrente. VIII. ENFERMEDADES NEUROLÓGICAS. 34. Migraña. 35. Síndrome parkinsoniano. IX. ENFERMEDADES DERMATOLÓGICAS. 36. Acné. X. ENFERMEDADES OCULARES. 37. Enfermedades oculares. 38. Contactología. XI. CONSEJO ANTE LAS DOLENCIAS DEL PACIENTE. 39. Fatiga. 40. Insomnio. 41. Dolor. XII. CONSEJOS ESPECÍFICOS Y DE PREVENCIÓN. 42. Consejos para la contracepción. 43. Menopausia. 44. Prevención de las enfermedades de transmisión sexual. 45. Nociones de dietética pediátrica. 46. Autovigilancia y autocontrol de la diabetes. 47. Consejos para el viajero. 48. Luchacontra el tabaquismo. 49. Tratamientos sustitutivos de las dependencias a opiáceos. 50. Donación de sangre. XIII. URGENCIAS Y CURAS ATENDIDAS EN LA FARMACIA. 51. Urgencias. 52. Curas. XIV. APÉNDICE. Expresiones habituales en la práctica del interrogatorio. Glosario. Índice alfabético de materias. | ||
| Nemire, Ruth E. Kier, Karen Pharmacy clerkship manual: a survival manual for students 2002, 304 Págs., ISBN: 0-07-136195-2 83,00 Euros (IVA incluido) |
Featuring a strong patient orientation, this clerkship manual develops therapeutic problem-solving skills, and sharpens knowledge of the appropriate use ofmedications. The book is unique in providing a wealth of case presentations, drug information, medical terminology, and diagnostic material. Included are detailed chapters covering preparation for a rotation, ethics of practice, communications, federal laws and regulations, physical assessment, pharmacokinetics, nutrition, pharmaceutical care, and community & hospital practice rotations. | ||
| Pelkonen, O. Baumann, A. Reichel, A. Pharmacokinetic challenges in drug discovery 2002, 304 Págs., ISBN: 3-540-42585-3 87,30 Euros (IVA incluido), |
INDICE: Davis, Dixon et al.: Accelerating
the Process of Drug Discovery;Lin: Role of Pharmacokintetics in Drug
Discovery; Mannens, Bohets, et al.: RapidPermeability Screening in Drug
Discovery toPredict Human Intestinal Absorption; Bayliss, Eddershaw: DrugMetabolism Assays and Their Use in Drug Discovery; Lavé, Luttringer et al.: Prediction of Human Pharmacokinetics Based onPreclinical In vitro and In vivo Data; Pelkonen, Hukkanen etal.: In Vitro Screening ofCytochrome p450 (CYP) Induction Potential; Fricker: Drug Transport Accross the Blood-Brain Barrier; Olah: The Development and Implementation of BioanalyticalMethods using LC/MS to Support ADME Studies..; Mandagere: Strategies in LeadSelection and Optimization; Smith: HighThroughput Screening , Brains versus Brawn; Van de Waterbeemd:Relation of Molecular Properties with Drug Absorption and Disposition; Lewis: Modelling Human Cytochrome P450-Substrate Interactions; Forum Discussion. |
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| Young, Lloyd Yee; Koda-Kimble, Mary
Anne; Guglielmo, B. Joseph; Kradjan, Wayne A. Applied therapeutics handbook 2002, 1100 Págs., ISBN: 0-7817-3484-3, 7ª Edic., 65,20 Euros (IVA incluido) |
Designed as a pocket version to accompany
the text, Applied Therapeutics: Clinical Use of Drugs, Seventh Edition
, this portable handbook contains key reference material that summarizes
important text with practical information in a condensed format. It
follows the same chapter structure as the text and employs a system/disorder-based approach in its presentation. Includes a comprehensive scope of areas as they relate to drug information, and covers such topics as dermatology, psychiatry, oncology, drug abuse, and more. Features several tables that are easily accessible for locating key information effectively at a glance. |
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| Ash, Michael; Ash, Irene Handbook of pharmaceutical additives 2001, 1000 Págs., ISBN: 0-566-08504-6, 2ª Edic., 680,60 Euros (IVA incluido) |
It describes more than 5000 trade name
and more than 3000 generic chemical components that are used in the
formulation of both prescription and over-the-counter drugs. These additives
enable or enhance the therapeutic delivery of theactive ingredients
in a variety of medications that include orals, topicals,
suppositories, injectables, inhalants, etc.The chemical and material additivescontained
in this reference serve to: improve flow, taste, appearance; aid product uniformity; increase stability; and control bioavailability. Additive ingredients are an essential part of the pharmaceutical formulation and information about these chemicals and materials is critical to the manufacturer, quality controller, pharmacist, physician, and consumer.The reference contains detailed profiles on both the trade name and generic chemical additives. All tradename entries are cross-referenced to their generic components. Trade names and generic chemicals are indexed by function, application, CAS and EINECS/ELINCS numbers. Ingredients that are approved by the FDA or recommended by USP/NF, BP, or Eur. Ph. are noted in the individual entries and summarized in an Appendix. Over 2000 manufacturers of these pharmaceutical-grade products are listedwith full contact information, including email and internet addresses. |
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| Challener, Cythia A. Chiral drugs 2001, 672 Págs., ISBN: 0-566-08411-2 500,82 Euros (IVA incluido), |
INDICE: Part 1 Chirality: overview of
chirality; drivers for the chiral market; sources of chiral compounds;
methodologies for obtaining chiral compounds - examples. Part 2 Main
entries. Part 3 Indexes: CAS RN index; EINECS index;name and synonym
index. Part 4 Manufacturer and supplier directory |
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| Jimenez Torres, N.V.; Merino
Sanjuan, Matilde;
Almenar Cubells, Daniel Fármacos antineoplásicos y de soporte en el tratamiento del cáncer 2001, 450 Págs., ISBN: 84-607-1784-4 60,10 Euros (IVA incluido) |
INDICE: Presentación. Fármacos antineoplásicos LO1A agentes alquilantes, L01Bantimetabolitos. LO1C antineoplásicos de origen vegetal. LO1D antibióticos citostáticos. LO1E preparados hormonales. LO1F inmunomodulares. LO1G otros antineoplásicos. FARMACOS DE SOPORTE: LO1G1B preventivos de efectos secundarios. Estimulantes de la hematopoyesis. AO4 antieméticos. Anexos. Glosario de términos. Direccion de internet. Bibliografia general. Indice alfabético de fármacos ynombres registrados. Indice alfabético de nombres registrados y fármacos. | ||
| Alba Romero, Susana Farmacia: un acercamiento a través de su historia 2001, 262 Págs., ISBN: 84-89922-53-5 30,00 Euros (IVA incluido) |
INDICE: Introducción. PRIMERA PARTE FARMACIA
DESDE EL MUNDO ARCAICO A LA EDADMEDIA. Antecedentes de la farmacia. El sanador y sus funciones de sacerdote, mago y curandero en le mundo arcaico. El conocedor de los remedios curativos en las civilizaciones antiguas. Civilizaciones antiguas extinguidas Mesopotamia.. El pensamiento racional y la farmacoterapia en la antigüedad clásica.. SEGUNDA PARTE FARMACIA DESDE LA BAJA EDAD MEDIA AL SIGLO XX. La farmacia a través de la legislación. Significativos del mundo farmacéutico en la legislación delsiglo XX. La farmacia a través del ejercicio profesional. La farmacia a través del medicamento desde la Baja Edad Media al siglo XX. La farmacia a través de las farmacopeas, desde el renacimiento al siglo XX. Obras citadas y bibliografía complementaria. Anexos. |
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| Spiegelhalter, David; Abrams, Keith Bayesian approaches to evaluating health care inteventions 2002, 350 Págs., ISBN: 0-471-49975-7 116,77 Euros (IVA incluido) |
The Bayesian approach involves collecting
data from past experience in order to reach conclusions about future
events. There are a large number of books onBayesian analysis, but very
few that cover clinical trials and biostatisticalapplications in any
capacity. There is no book available that is introductoryin nature and
covers such a broad array of essential topics. This book provides a
valuable overview of this rapidly evolving field, not only for statisticians
in the pharmaceutical industry, but also to anyone involved in conducting
clinical trials and HTA work. l Comprehensive coverage of Bayesian methods
in medical research l Illustrated throughout by case studies and worked
examples l Includes methods and applications that are encouraged by
regulatory bodies lAuthors are at the forefront of research into Bayesian
methods in medical research l Suitable for those with a limited statistical background l Accompaniedby a Web site featuring data sets and worked examples in WinBUGS - the most widely accepted Bayesian modelling package |
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| Levin, Michael Pharmaceutical process scale-up 2001, 560 Págs., ISBN: 0-8247-0625-0 49.131 Ptas. (IVA incluido), |
Concentrates on the theory and practice of transferring pharmaceutical processes from laboratory scale to the pilot plant and production scale. Covers parenteral and nonparenteral liquids and semi-solids, products derived from biotechnology, dry blending and power handling, granulation and drying, fluid bed applications, compaction and tableting, and film coating. | ||
| Ohannesiananthony, Lena;
Streeter, J. Handbook of pharmaceutical analysis @SERIE = Drugsand the pharmaceutical sciences 2001, 608 Págs., ISBN: 0-8247-0462-2 295,28 Euros |
Provides recent techniques as well as contemporary applications for the selection, preparation, and analysis of pharmaceutical compounds. Contains a convenient, easy-to-use index, facilitating quick access to each compound discussed. | ||
| Salazar Macián, Ramón Gestión de la calidad en el desarrollo y fabricación industrial de medicamentos, 2 vols. 2001, 1198 Págs., ISBN: 84-931913-0-2, 1ª Edic. 178,77 Euros |
INDICE: TOMO I: Gestión de la calidad.
Aplicación de un sistema de garantía de calidad. Introducción a las
buenas prácticas de fabricación, buenas prácticas de laboratorio y buenas
prácticas clínicas. Estudios de preformulación. Estudios de formulación.
Formulación de formas de dosificación sólidas de administración oral:
comprimidos. Casos prácticos. Formulación de formas de dosificación
sólidas de administración oral: comprimidos de liberación modificada
y pellets. Casos prácticos... TOMO II: Aplicación de las GMP al diseño
de plantas farmaceúticas. Estudio del diseño de nuevas plantas farmaceúticas. Sistemas de tratamiento de agua en la industria farmaceútica. Sistemas de tratamiento de aire en la industria farmaceútica. Diseño de instalaciones y equipos para la fabricación industrial de medicamentos sólidos de administración por vía oral. Planificación de la producción. Aplicación del concepto de calidad total a la industria farmeceútica. Validación industrial... |
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| Swarbrick, James Boylan, James C. Encyclopedia of pharmaceutical technology 2002, ISBN: 0-8247-2825-4, 2ª Edic. |
New topics in the second
edition include advertising and promotion of prescription and over the
counter drug products, drug delivery via liquid inhalation,mixing and
segregation in tumbeling blenders, outsourcing of pharmaceuticals,paperless
documentation systems, scale-up and post-approval changes, and x-ray powder diffractometry. |
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| Barbé Rocabert, Coloma Preparados farmacéuticos y parafarmacéuticos: bases tecnológicas y documentales 2001, 316 Págs., ISBN: 84-458-1126-6 30 Euros |
Este libro corresponde al módulo profesional
de Elaboración de preparados farmacéuticos y parafarmacéuticos en establecimientos
de farmacia del ciclo formativo de grado medio Técnico en Farmacia.
Este ciclo tiene por finalidad formara los profesionakes que participarán
en los procesos de dispensación, venta ydistribución de productos de farmacia y parafarmacia, en la realización de análisis clínicos sencillos y en la realización de operaciones fisicoquímicas elementales para la elaboración de productos farmacéuticos y parafarmacéuticos, bajo la supervisión correpondiente. |
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| Garcia Garcia, Francisco Javier Validacion de métodos analíticos 2001, 330 Págs., ISBN: 84-89602-33-6 29,66 Euros |
INDICE: Abreviaturas. Glosario. Parte I: Generalidades. Parte II: Validación de métodos de análisis en materias primas y especialidades farmacéuticas. Parte III: Validación de métodos de análisis en microbiología. Parte IV: Validación de métodos en bioanálisis. Parte V: Estadística aplicada. Apéndice | ||
| Barrio Sánchez, Horacio del; Eguilleor Villena,
Alejandro; Fernández Román, Mario; Gamarra Otero, Carmen Gestión de la calidad en la oficina de farmacia: manual para la implantación de un sistema de la calidad en la oficina de farmacia, conforme a la nor 2001, 149 Págs., ISBN: 84-607-3161-8 18,03 Euros |
INDICE: Introducción. 1.Qué es un sistema de la calidad? 2.Actividades farmacéuticas. 3.Implantación del sistema de la calidad. Apéndice: Definiciones, Bibliografía, Abreviaturas y acrónimos, ejemplos de impresos par registros de datos. |
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| Ansel, Howard C. Stoklosa, Mitchell J. Pharmaceutical calculations 2001, 396 Págs., ISBN: 0-7817-3172-0, 11ª Edic. 70,13 Euros |
This Eleventh Edition text offers a comprehensive presentation of the fundamental principles and basic techniques involved in applying pharmaceutical calculations in community, hospital and industrial settings. New chapters cover contemporary compounding, calculations involving veterinary pharmaceuticals, bodymass index and the nutrition label calculations associated with plant extractives, and a miscellaneous chapter combining relevant calculation topics from formerly separate appendices. Important changes to existing chapters include the incorporation of dosing considerations in chemotherapy and heparin dosing; calculations relevant to body electrolyte and water requirements; the quantitative determination of active drug moiety when present in chemically combined forms; and, a revised treatment of aliquot measuring. Includes over 100 new practice problems. | ||
| Brittain, Harry G. Analytical profiles of drug substances and excipients, vol. 28 2001, 338 Págs., ISBN: 0-12-260828-3, Cartoné 242,02 Euros |
INDICE: Description. Method (s) of
preparation. Physical properties. Methods of analysis. Stability. Drug metabolism and pharmacokinetics |
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| Mingo, G.J. Dispensación y venta de productos farmacéuticos y parafarmacéuticos 2001, 248 Págs., ISBN: 84-481-3003-3, Rústica 16,79 Euros |
INDICE: I. Oficina de farmacia. 1. Sistema
sanitario español. Conceptos generales. 2. Función sanitaria de la oficina
de farmacia. II. Dispensación y venta de productos farmacéuticos y
parafarmacéuticos.
3. Dispensación de medicamentos sin receta médica. 4. Dispensación de medicamentos con receta médica. 5.Dispensación de medicamentos en el servicio de farmacia hospitalaria. 6. Dispensación de productos parafarmacéuticos y plantas medicinales. 7. Especialidades farmacéuticas. 8. Fórmulas magistrales y formulación homeopática. III. Educación para la salud. 9. Salud y enfermedad. 10. Educación sanitaria. Higiene. 11. Infección y profilaxis. 12. Parámetros somatométricos. Constantes vitales.Primeros auxilios. IV. Farmacología básica. 13. Origen y naturaleza química de los fármacos. 14. Acción farmacológica de los medicamentos. 15. Farmacocinética. 16. Dosificación de los fármacos. Indicaciones. 17. Intoxicación. Valoración biológica. 18. Vías de administración de medicamentos. Generalidades. V. Productos sanitarios expendidos en farmacia. 19. Material de cura. Otros equipos sanitarios. 20. Materiales de incisión, punción y sutura. 21. Productos de ortopedia. |
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| Goodman, L. Goodman and Gilman's. The Pharmacological Basis of Therapeutics 10th ed. McGraw-Hill. Fecha de publicación: 15 SEP 2001 |
This work aims to provide a comprehensive and
up-to-date correlation of pharmacology with related medical sciences, a re-interpretation of the actions and uses of drugs from the view point of the latest advances in medicine and places emphasis on the application of pharmacodynamics in therapeutics. |
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| Salazar Macián, Ramón Gestión de la calidad en el desarrollo y fabricación industrial de medicamentos, 2 vols. ISBN: 84-931913-0-2, 1ª Edic., 2001, 1198 Págs. |
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| Barel, A. O.; Paye, Marc
Maibach, Howard I. Handbook of cosmetic science and technology ISBN: 0-8247-0292-1 2001, 888 Págs. |
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| Koda-Kimble, Mary Anne; Young, Lloyd Yee Applied therapeutics: the clinical use of drugs ISBN: 0-7817-3137-2, 7ª Edic., 2001, 3008 Págs., |
INDICE: I. GENERAL PRINCIPLES 1. Assessment of Therapy and Pharmaceutical Care 2. Interpretation of Clinical Laboratory Tests 3. Herbs and Other DietarySupplements 4. Drug Allergy and Anaphylaxis 5. Managing Acute Drug Toxicity II. GENERAL CARE 6. Nausea and Vomiting 7. Pain 8. Perioperative Care 9. Acid-Base Disorders 10. Fluid and Electrolyte Disorders III. CARDIAC AND VASCULAR DISORDERS 11. Dyslipidemias 12. Essential Hypertension 13. Peripheral Vascular Disorders 14. Thrombosis 15. Ischemic Heart Disease 16. Myocardial Infarction 17. Heart Failure 18. Cardiac Arrhythmias 19. Hypertensive Emergencies 20. Shock IV. PULMONARY DISORDERS 21. Asthma 22. Chronic Obstructive Pulmonary Disease23. Acute and Chronic Rhinitis 24. Drug-Induced Pulmonary Disorders V. GASTROINTESTINAL DISORDERS 25. Upper Gastrointestinal Disorders 26. Inflammatory Bowel Disease 27. Alcoholic Cirrhosis 28. Adverse Effects of Drugs on the Liver VI. RENAL DISORDERS 29. Acute Renal Failure 30. Chronic Renal Failure 31. RenalDialysis 32. Dosing of Drugs in Renal Failure 33. Solid Organ Transplantation VII. NUTRITION ISSUES 34. Adult Enteral Nutrition 35. Adult Parenteral Nutrition VIII. SKIN DISORDERS 36. Dermatotherapy 37. Acne 38. Psoriasis 39. Photosensitivity and Burns IX. ARTHRITIC DISORDERS 40. Gout and Hyperuricemia 41. Rheumatic Disorders 42. Connective Tissue Disorders: The Clinical Use of Corticosteroids X. WOMEN,S HEALTH 43. Contraception 44. Obstetrics 45. Teratogenicity and Drugs in Breast Milk 46. Gynecological Disorders XI. ENDOCRINE DISORDERS 47. Thyroid Disorders 48. Diabetes Mellitus XII. EYE DISORDERS 49. Eye Disorders XIII. NEUROLOGICAL DISORDERS 50. Headache 51. Parkinson's Disease 52. Seizure Disorders 53. Cerebrovascular Disorders XIV. INFECTIOUS DISEASES 54. Principles of Infectious Diseases 55. Antimicrobial Prophylaxis for Surgical Procedures 56. CNS Infections 57. Endocarditis 58. Respiratory Tract Infections 59. Tuberculosis 60. Infectious Diarrhea 61. Intra-Abdominal Infections 62. Urinary Tract Infections 63. Sexually Transmitted Diseases 64. Osteomyelitis/Septic Arthritis 65. Traumatic Skin and Soft Tissue Infections 66. Infections in Neutropenic Patients 67. Pharmacotherapy of Human Immunodeficiency Virus (HIV) 68. Opportunistic Infection to HIV Patients 69. Fungal Infections 70. Viral Infections 71. Viral Hepatitis 72. Parasitic Infections 73. Tick-Borne Disease XV. PSYCHIATRIC DISORDERS 74. Anxiety Disorders 75. Sleep Disorders 76. Schizophrenia 77. Mood Disorders I: Major Depressive Disorders 78. Mood Disorders II: Bipolar Disorders 79. Psychiatric Disorders in Children, Adolescents, and People with Developmental Disabilities 80. Secondary Neuropsychiatric Disorders 81. Eating Disorders/Weight Management XVI. SUBSTANCE ABUSE 82. Psychoactive Substance Use Disorders 83. Alcohol Abuse XVII. HEMATOPOIETIC DISORDERS 84. Anemias 85. Drug-Induced Blood Disorders XVIII. NEOPLASTIC DISORDERS 86. Neoplastic Disorders and Their Treatment: General Principles 87. Adverse Effects of Chemotherapy 88. Hematological Malignancies 89. Solid Tumors 90. Hematopoietic Cell Transplantation XIX. PEDIATRICS 91. Pediatric Considerations 92. Neonatal Therapy 93. Immunizations 94. Pediatric Infectious Diseases 95. Pediatric Nutrition 96. Cystic Fibrosis XX. GERIATRIC THERAPY 97. Geriatric Rehabilitation and Drug Use 98. Geriatric Dementias 99. Geriatric Urological Disorders. |
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| Major pharmaceutical companies of the
world 2001 2001, ISBN: 1-86099-247-2, 3ª Edic. |
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| Calvey, T. N., Williams, N. E. Principles and practice of pharmacology for anaesthetists 2001, 368 Págs., ISBN: 0-632-05605-3, 4ª Edic |
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| Medicom. Vademecum Internacional 2000. ( Incluye CD-ROM ) ISBN: 84-89327-10-6 2001, 1996 Págs. |
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| Physicians drug handbook ISBN: 1-58255-065-4, 9ª Edic. 2001, 1312 Págs., |
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| Profesional's handbook of drug therapy
for pain ISBN: 1-58255-102-2 2001, 768 Págs. |
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| Stein, Christopher Opioides en el control del dolor: aspectos básicos y clínicos ISBN: 84-458-1028-6 2001, 348 Págs. |
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| Feinberg, M. L'assurance qualité dans les laboratoires agroalimentaires et pharmaceutiques ISBN: 2-7430-0458-4, 2ª Edic., 2001, 384 Págs., |
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| Preventing medication errors: strategies
for pharmacists ISBN: 0-86688-697-4, Rústica 2001, 150 Págs., |
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| Young, Thomas E. Barry Magnum, O. Neofax ISBN: 1-888703-13-X, 13ª Edic., , Espiral 2000, 264 Págs., |
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| APhA Tableting specification manual ISBN: 1-58212-005-6, 5ª Edic., , Espiral 2001, 119 Págs., |
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| C.O.F.B. Catalogo de especialidades farmaceuticas 2001 ISBN: 84-87276-43-1, Rústica 2001, 2883 Págs. |
Indice de especialidades por orden alfabético. |
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| Ehrenpreis, Seymour Clinician's handbook of prescription drugs ISBN: 0-07-134385-7, Rústica 2001, 640 Págs. |
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| Villa Alcázar, Luis F. Medimecum: Guia de terapia farmacologica. 2001 ISBN: 84-931386-1-4, Rústica 2001 |
INDICE:
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| Cindoc. Recursos para farmacéuticos en Internet: manual y fuentes de información ISBN: 84-00-07872-1 2000, 167 Págs.
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INDICE
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| Gennaro, Alfonso R. Remington: the science & practice of pharmacy 2000, 2000 Págs., 20ª Edición (Noviembre 2000) Plenum Pub Corp; ISBN: 0306464047 |
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| Moral Gadeo, Juan Dispensación y venta de productos farmacéuticos y parafarmacéuticos ISBN: 84-95391-77-5 2000, 316 páginas |
INDICE:
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| Yoshioka, Sumie Stella, Valentino J. Stability of drugs and dosage forms 2000, 272 Págs., (Noviembre 2000) Plenum Pub Corp; ISBN: 0306464047 |
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| Testa, Bernard Pharmacokinetic optimization in drug research: biological, physicochemical, and computational strategies 2000, 500 Págs., |
INDICE:
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"Instalaciones
de Producción Farmacéutica. Diseño y aplicaciones"
AEFI Sección Centro ha
realizado una nueva publicación titulada "Instalaciones de Producción
Farmacéutica. Diseño y aplicaciones". Esta obra de Graham C. Cole,
especialista en procesos farmacéuticos es una traducción al castellano de la
publicación "Pharmaceutical Production Facilities. Design
and applications" 2ª edición de 1998. Ed. Ellis Horwood.
Este libro en inglés era ya
conocido como publicación de interés sobre instalaciones farmacéuticas.
El libro consta de 15 capítulos
que son los siguientes:
1.-
Introducción
2.-
Diseño y gestión del proyecto.
3.-
Elección del emplazamiento.
4.-
Flujo del proceso.
5.-
Sistemas de servicio para procesos farmacéuticos.
6.-
Consideraciones en el diseño de una instalación farmacéutica.
7.-
Salas limpias.
8.-
Sistemas de producción de comprimidos.
9.-
Sistemas de recubrimiento de comprimidos.
10.-
Sistemas de llenado de cápsulas.
11.-
Diseño de una instalación de fabricación estéril y aséptica.
12.-
Sistemas especiales de producción.
13.-
Sistemas de fabricación flexibles y automatización.
14.-
Sistemas de envasado.
15.-
Validación.
El libro en inglés se podía
comprar en las librerías científicas al precio de 210'35 euros (35.000.- ptas).
La edición en castellano es limitada y el precio de venta es de 120 euros
(20.000.-pta)
Las personas interesadas en
comprarlo deberán hacer la reserva del mismo, ya que la edición es limitada,
en al secretaría de AEFI Centro. Telf: 914573543.
*****************************************
|
MANUAL DE FARMACIA CLÍNICA Y ATENCIÓN FARMACÉUTICA |
| Historia de la Farmacia y Medicina | |
| López Pérez, Miguel Asclepio renovado: alquimia y medicina en la España moderna (1500-1700) Editorial: CORONA BOREALIS EDICIONES 2003, 351 Págs., ISBN: 84-95645-47-5, Rústica 16,00 Euros (IVA incluido) |
INDICE: Cuestiones preliminares. Los médicos
humanistas. Boticarios, alquimiay cien años de destilación. La religión como puente hacia el siglo XVII. Alejandro Quintilino. Mitad del siglo: un caldero en ebullición. Los hijos de paracelso. |
| El fago 29 y los orígenes de
la biología molecular en España Editorial: C.S.I.C. (Cons.Sup.Inv.Cient. 2003, 435 Págs., ISBN: 84-00-08147-1, Rústica Precio aproximado: 46,00 Euros (IVA incluido) |
En este libro, los compañeros y discípulos
el profeor Eladio Viñuela muestran, a travé de artículos cortos, su excelencia no sólo como un gran investigador, sino también como un escelente ser humano, cuyo mayor error fue dejarnos cuando aún era un muy joven |
| Alonso Guardo, Alberto Los pronósticos médicos en la medicina medieval: el tractatus de crisi et de diebus creticis de Bernardo de Gordonio Editorial: UNIVERSIDAD DE VALLADOLID 2003, 512 Págs., ISBN: 84-8448-233-2 Precio aproximado: 20 Euros |
Presentamos la primera edición
crítica del Tractatus de crisi et de diebus creticis de Bernardo de
Gordonio. Se trata de un texto medieval sobre medicina elaborado a
finales del S. XIII por uno de los médicos más famosos de la
importante Escuela de Medcina de Montpellier.
INDICE: Prólogo; 1. El autor y su entorno cultural. 2. El tratactus de Crisi et Diebus Creticis, una obra científico-didáctica. 3. Tradición textual. 4. Edición crítica, traducción y notas. 5. Glosario e índices. 6. Bibliografía |
| Puente, Cristina
de la Médicos de al-Andalus: Avenzoar, Averroes e Ibn al-Jatib NIVOLA LIBROS 2003, 128 Págs., ISBN: 84-95599-62-7, Rústica Precio aproximado: 14 Euros |
Los árabes conciben la
medicina de modo semejante a sus predecesores helenísticos. La botánica,
la farmacología o la higiene forman parte de una única ciencia que
tiene como objetivo primordial el conocimiento del cuerpo humano, la
capacidad de sanarlo cuando enferma y, sobre todo, la búsqueda de su
bienestar. En al--ndalus, extremo occidental del mundo musulmán, Avenzoar, Averroes e Ibn al-Jatib son herederos de la tradición médica árabe anterior y representan su culminación. Sus vidas se desarrollan ligadas a la corte musulmana y a sus soberanos, y muestran cómo las existencias de los personajes próximos al sultán penden del hilo de las intrigas palatinas. A pesar de la distancia en el tiempo que les separa y de que cada uno sirve a una dinastía diferente, los tres conocen la gloria y los privilegios derivados del poder político y también sufren la tragedia de la difamación y la persecución. |
| French, Roger Medicine before science: the business of medicine from the middle ages to the enlightenment CAMBRIDGE UNIVERSITY PRESS. 2003, 296 Págs., ISBN: 0-521-00761-5 |
HISTORIA DE LA MEDICINA |
| Alba Romero, Susana Farmacia: un acercamiento a través de su historia 2001, 262 Págs., ISBN: 84-89922-53-5 30,00 Euros (IVA incluido) |
INDICE: Introducción. PRIMERA PARTE FARMACIA
DESDE EL MUNDO ARCAICO A LA EDADMEDIA. Antecedentes de la farmacia. El sanador y sus funciones de sacerdote, mago y curandero en le mundo arcaico. El conocedor de los remedios curativos en las civilizaciones antiguas. Civilizaciones antiguas extinguidas Mesopotamia.. El pensamiento racional y la farmacoterapia en la antigüedad clásica.. SEGUNDA PARTE FARMACIA DESDE LA BAJA EDAD MEDIA AL SIGLO XX. La farmacia a través de la legislación. Significativos del mundo farmacéutico en la legislación delsiglo XX. La farmacia a través del ejercicio profesional. La farmacia a través del medicamento desde la Baja Edad Media al siglo XX. La farmacia a través de las farmacopeas, desde el renacimiento al siglo XX. Obras citadas y bibliografía complementaria. Anexos. |
| Porter, Roy Breve historia de la medicina Editorial: TAURUS. 2004, 304 Págs., ISBN: 84-306-0541-X, Rústica Precio aproximado:17,00 Euros |
Roy Porter nos ofrece una refrescante historia de la medicina para profanos en la que se refleja la evolución de la ciencia médica, la relación médico-paciente o la percepción de la enfermedad y la muerte. Se exploran las múltiples formas, tanto curiosas y creativas, como terribles en ocasiones, a las que ha recurrido la humanidad para luchar contra las enfermedades a lo largo de los siglos: desde los remedios alternativos hasta los antibióticos, desde los sangrados hasta los rayos X, desde las toscas amputaciones hasta los sofisticados transplantes de órganos. Con un extraordinario elenco de barberos, charlatanes, farmacéuticos, brujos y anatomistas, Roy Porter nos presenta una visión esclarecedora, divertida y, a menudo, terrorífica de nuestra continua búsqueda de la inmortalidad. |
| Cosmética, dermofarmacia | |
| Takeda, Katsuyuki Harada, Shotaro Functional cosmetology: substantiation of cosmetics efficacy : recent progress and future promise Editorial: YAKUJI NIPPO LTD. 2003, 611 Págs., ISBN: 4-8408-0737-X, Cartoné 457,52 Euros (IVA incluido), 76.125 Ptas. |
INDICE: PART 1 CHAPTER 1 SOCIAL USEFULNESS OF COSMETICS. Psychological effect of makeup. Effects of makeup in medicine. Importance of makeup in the care of the elderly. Psychological effect of fragances used in cosmetics. What cosmetics can contribute to health. CHAPTER 2 USEFULNESS OF COSMETICS IN DERMATOLOGY. Overall effects of cosmetics from the dermatological viewpoint. Aiming towards a common understanding between dermatology and cosmetic science. Significance of anti-oxidant effects in cosmetic science. |
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MANUAL
DE FARMACIA PRÁCTICA. (Primera Edición, Agosto 2003). Autor: Ruiz Martínez, Mª Adolfina Colección: Manuales/Ciencias de la Salud, núm. 9 Editorial: Universidad de Granada Materias: FAMB Idioma: Español Encuadernación: rústica sin solapa Color: malva 85 págs. (1 vol) - 17 x 24 cm Precio aproximado: 30 € |